चिकित्सा का भविष्य आंत के इर्द-गिर्द Future of Medicine Will Revolve Around the Gut

Author : Dr. P. D.GUPTA
Former Director Grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad, India
www.daylifenews.in
You can’t see them, but trillions — maybe quadrillions — of them travel in and out of your practice every day. They’re hungry, mysterious, community-oriented, and small. Very, very small.
They’re the microbes occupying your current patients’ guts.
Someday soon, you’ll prescribe medicine not just for humans but also for these microbes.
Evidence is mounting that the gut microbiota influences just about every major human disease. These trillions of microbes use our food to generate substances called metabolites that can protect or harm our health, with consequences reaching far beyond our gastrointestinal tracts. Long ago without knowing much Ayurvedic medicine advocated this concept.
Research has linked microbial metabolites to diabetes, cardiovascular disease, liver disease, obesity, high blood pressure, neurological disorders, depression, cancer (these are designated as Life Style diseases), and more. Now scientists are developing treatments targeting gut microbial pathways, designed to eliminate the bad metabolites and boost the good metabolites rather that symptomatic medicines.
The advantage is safety. By targeting the microbe instead of, say, an enzyme, the host (the patient) must absorb little if any drug.Implications for the future of medicine are huge. “Gut microbial pathways contribute to diabetes, obesity, virtually everything,” “Therapies that target gut microbiota processes will probably even be used for psychiatric disorders.
How it works: When you eat, your microbes eat, breaking down food into metabolites that interact with the thin layer of epithelial cells lining your gut. Some can be absorbed through the lining and into your bloodstream, a phenomenon known as “leaky gut.” Once in your blood, they can trigger irritation and inflammation, potentially leading to a wide variety of health issues, from gas and bloating to autoimmune conditions and mood disorders. Metabolites can influence how these immune cells work, possibly explaining why each person’s immune system behaves distinctively.Of the 1000-plus metabolites linked to the gut microbiome, scientists have identified several that matter
The gut microbiome can also regulate testosterone, with studies showing microbial differences in men with high testosterone vs those with less. For most people, the first step to fostering healthier microbial metabolites is much simpler: Diversify your diet.”A lot of folks are missing that diversity,” “Eat foods and experiment with foods that you might not eat all the time,” especially fruits, vegetables, nuts, seeds, and beans.
You are What Your Mother Ate
The things that parents do and eat can change what traits they pass on to their unborn babies. General rule of pregnancy: whatever mother eats, drinks, or breathes, so does the unborn child. Placenta does not filter out harmful substances (like carbon monoxide and nicotine inhaled as smoke) toxins inhaled get passed directly into the bloodstream of the unborn baby. Nicotine and carbon monoxide significantly reduce the amount of oxygen in the baby’s blood.
In 2024 it is also shown that even father’s diet can also influence the child’s health. Human fathers with high body-mass index have male offspring with metabolic disorders.
In other words in order to keep our gut microbes happy we should dowhat is said in this article. (The author has his own study and views)

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